Advice Pool - Health and Fitness

Plyometrics is the name for a type of exercise developed to increase a muscle-groups power to generate a large amount of force quickly. It may be used, for example, to improve the

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

throwing power of a football quarterback or the effectiveness of a boxer’s punch. Unlike traditional strength training exercises, plyometric exercises are performed quickly and exp

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

osively. The most common plyometric exercises include hops, jumps and bounding movements. One popular plyometric exercise is jumping off a box and rebounding off the floor back ont

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

o the box. Another is the clap push-up. Plyometric training exploits the muscles' cycle of lengthening and shortening to increase muscle power. Plyometric exercises start with a ra

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

id stretch of a muscle (the eccentric phase) followed by a rapid shortening of the same muscle (the concentric phase).

Plyometrics can be traced to Russia approximately 40 years a

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

o when it was developed for the Russian Olympic team. Dr. Yuri Verkhoshansky is credited with creating the principle, which at the time was known as "shock training". While observi

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

ng athletes, he realized that they had more strength and power coming out of a higher altitude landing when their muscles were stretched as opposed to a normal jump. The word plyom

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

tric comes from the Latin “plyo” and “metrics” meaning “measurable increases”, because his studies with elite athletes showed measurable increases using the technique.

There are

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

thousands of plyometric exercises, ranging from low intensity leg hops to high intensity drills such as box jumps, frog leaps, and burpies. Although these are typically associated

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

ith plyometric training for the adult athlete, common games and activities such as hop-scotch, jumping rope and jumping jacks can also be characterized as plyometrics because every

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

time the feet make contact with the ground the quadriceps are subjected to the stretch-shortening cycle. In fact, plyometrics are a natural part of many movements, as evidenced by

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

the leaping, hopping and skipping seen when children play.

Physical fitness trainers have long used apparatus to assist with plyometrics. For example, one plyometric exercise inv

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

lves catching and tossing a medicine ball to an assistant while the exerciser lies on his back. The triceps and chest muscles work both while they are lengthening during the catch

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

and while contracting during the toss.

Plyometrics (and any impact exercise) can cause injury if you don't warm up first and follow prudent safety precautions. The force generated

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

during these moves requires that athletes use them carefully and with proper training. They should only be attempted if you already have good levels of strength, flexibility, and b

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

lance. A safe and effective plyometric program stresses quality, not quantity. Safe landing techniques, such as landing from toe to heel from a vertical jump, and using the entire

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

foot as a rocker to dissipate landing forces over a greater surface area are important to reduce impact forces. In addition, visualization cues, such as picturing oneself landing

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

light as a feather” and “recoiling like a spring” after impact promotes low-impact landings. When landing it is important to avoid excessive side-to-side motion at the knee. Landi

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

ng forces can be absorbed through the knee musculature (quadriceps, hamstrings, and calf muscle) more effectively when the knee is bending primarily in only one plane of motion. Du

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

to the potential for injury and numerous different types of plyometrics available, it is advisable to work with a physical fitness trainer if you plan to use them in your training

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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