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Advice Pool - Blood Doping for Boosting Exercise Performance
As with any athletic event focusing on the extremes of human exercise performance, the Winter Olympics have allowed the ugly head of cheating in sport to rise again. Recently, police raided the Austrian ski team’s residences in Torino on suspicion of blood
According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product
doping to improve athletic performance. What is blood doping anyway and how does it improve athletic performance? This article provides some basic information on blood doping, explains the mechanisms for its ability to greatly improve exercise performanc
; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.
Examples of combination products may in
Examples of combination products may in
e and provides pros and cons for it’s use.
Doping in sports
Although the word hints at a relationship, doping actually has nothing to do with "dope" (the street word for marijuana). If this were the case, it may be that snowboarders would be under
Doping in sports
Although the word hints at a relationship, doping actually has nothing to do with "dope" (the street word for marijuana). If this were the case, it may be that snowboarders would be under
lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.
investigation instead of skiers!
Doping for exercise performance improvement refers specifically to "blood doping" - a means of cheating by artificially boosting red blood cell counts.
The doping procedure works like this:
A doctor draws up to 4 u
Doping for exercise performance improvement refers specifically to "blood doping" - a means of cheating by artificially boosting red blood cell counts.
The doping procedure works like this:
A doctor draws up to 4 u
here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe
nits (about 4 pints) of blood from the athlete's body - essentially making him/her anemic (low blood cell count)
The withdrawn blood is then centrifuged (spun very quickly) to separate the red blood cells (RBCs) from the other main component of blood – pla
The withdrawn blood is then centrifuged (spun very quickly) to separate the red blood cells (RBCs) from the other main component of blood – pla
d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.
Combination pro
Combination pro
ma.
The athlete’s RBCs are "stored" under refrigerated conditions (the shelf life of RBCs is about 40 days)
The anemic condition stimulates the athlete's body to increase production and release of a hormone called EPO (erythropoietin)
EPO stimulates the
The athlete’s RBCs are "stored" under refrigerated conditions (the shelf life of RBCs is about 40 days)
The anemic condition stimulates the athlete's body to increase production and release of a hormone called EPO (erythropoietin)
EPO stimulates the
ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc
replenishing of the "lost" RBCs
The athlete is given about 4 weeks to fully replenish their RBC count to pre-drawing levels
The athlete’s stored RBCs are then re-infused into the athlete’s body, boosting the RBC level higher
Why do athletes participat
The athlete is given about 4 weeks to fully replenish their RBC count to pre-drawing levels
The athlete’s stored RBCs are then re-infused into the athlete’s body, boosting the RBC level higher
Why do athletes participat
easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi
in blood doping and what is the logic behind it?
Quite simply - blood doping can quite significantly improve performance in long duration, endurance-type exercise such as cross-country skiing, skating and running.
The logic for its use it to boost th
Quite simply - blood doping can quite significantly improve performance in long duration, endurance-type exercise such as cross-country skiing, skating and running.
The logic for its use it to boost th
nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically
e oxygen carrying capacity of the blood above normal levels providing more oxygen to the working muscles - allowing for a greater power output and a decreased susceptibility to fatigue.
RBCs contain a protein called hemoglobin – the primary “transporter” o
RBCs contain a protein called hemoglobin – the primary “transporter” o
and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ
oxygen from the lungs to the rest of the body including the working muscles. So if you boost the number of RBCs you also boost the amount of “available” hemoglobin to bind and deliver oxygen.
The pros to blood doping use:
It is highly effective a
The pros to blood doping use:
It is highly effective a
ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi
nd is estimated to improve endurance exercise performance at the elite level by about 4%
It boosts VO2 max (maximal oxygen uptake) and reduces lactate buildup
The ergogenic (exercise performance boosting) effect with blood doping is immediate, making it i
It boosts VO2 max (maximal oxygen uptake) and reduces lactate buildup
The ergogenic (exercise performance boosting) effect with blood doping is immediate, making it i
ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.
Following aspects would a
Following aspects would a
deal for a pre-main event performance - making pre-event detection more difficult
It may be easier to regulate hematocrit (percent composition RBCs of total blood volume) – a tightly regulated ceiling is placed on this value and is used for detection of bo
It may be easier to regulate hematocrit (percent composition RBCs of total blood volume) – a tightly regulated ceiling is placed on this value and is used for detection of bo
dd to the challenges in developing combination products:
Which markets to tap where the combination products can do fairly well?
Which combination prod
Which markets to tap where the combination products can do fairly well?
Which combination prod
h blood doping (and EPO use)
It probably decreases the perception of effort during exercise allowing for improved performance
The cons to blood doping use:
The blood doping process is quite laborious and quite severely decreases the training capac
It probably decreases the perception of effort during exercise allowing for improved performance
The cons to blood doping use:
The blood doping process is quite laborious and quite severely decreases the training capac
cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin
ity of the athlete in the first few weeks after blood donation as the athlete is essentially anemic and cannot exercise as hard.
1. Health risks
With the increase in hematocrit the heart needs to work much harder to pump the higher viscosity blood
1. Health risks
With the increase in hematocrit the heart needs to work much harder to pump the higher viscosity blood
tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen
What would be the developing cost?
How to tackle the risks encountered during combination product developmen
increasing the risk of overload damage to the heart such as myocardial infarct (heart attack)
There is an increased risk of developing life-threatening blood clots (stroke, heart attack, lung clot)
Blood doping involves transfusion using needles and some
There is an increased risk of developing life-threatening blood clots (stroke, heart attack, lung clot)
Blood doping involves transfusion using needles and some
t?
As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel
As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel
times donor blood, so there is a greater risk of infections such as hepatitis A and B and even AIDS
Since the athlete’s RBCs are externally stored, there is a greater risk to the athlete if this has been done incorrectly (e.g. storage at the incorrect temp
Since the athlete’s RBCs are externally stored, there is a greater risk to the athlete if this has been done incorrectly (e.g. storage at the incorrect temp
ping new procedures for reviewing their safety, efficacy and quality.
Professional from academic institutions, pharmaceutical industries, health care indust
Professional from academic institutions, pharmaceutical industries, health care indust
rature, tampering, confusion/mislabeling)
2. Status risks
Detection of the use of blood doping may defile the athlete’s reputation
Detection may result in him or her being banned from competition, as sport regulating agencies such as the IOC and s
2. Status risks
Detection of the use of blood doping may defile the athlete’s reputation
Detection may result in him or her being banned from competition, as sport regulating agencies such as the IOC and s
y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products
everal cycling governing bodies strictly forbid it.
Actually, blood doping in sports has become less popular recently due to the increased availability of recombinant erythropoietin (rEPO) which as explained in an article on this website produces exactly t
Actually, blood doping in sports has become less popular recently due to the increased availability of recombinant erythropoietin (rEPO) which as explained in an article on this website produces exactly t
.
As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de
As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de
e same effect as blood doping but is easier, less riskier and more effective (boosts endurance performance by about 6%).
In conclusion, this article has shown that although blood doping and rEPO may quite significantly boost endurance exercise performance,
In conclusion, this article has shown that although blood doping and rEPO may quite significantly boost endurance exercise performance,
elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.
Companies that provide selfless information through particip
Companies that provide selfless information through particip
it carries with it risks to the athlete’s health and status. It is unfortunate, but with increases in modern technology and molecular biology, it is likely that even these forms of “cheating” will someday be replaced with safer and less detectable methods
tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products
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