Advice Pool - Health and Fitness

You will not become a better athlete by doing the same training reg

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

imen each day. Athletes train by taking hard workouts on one day, f

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

eling sore on the next, and not taking another hard workout until t

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

e muscles stop feeling sore.

It's called the hard-easy principle.

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

If you want to become stronger or faster or increase your endurance

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

you have to exercise hard or long enough to make your muscles burn

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

Then your muscles will be sore for one or more days. If you try to

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

exercise hard when your muscles are damaged, you will tear them an

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

the muscles will weaken. If you wait for the soreness to disappear

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

your muscles will be stronger than they were before your workout.

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

s you continue to take stressful workouts only after the soreness d

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

isappears, you will become progressively stronger and faster and ha

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

e greater endurance. Athletes in most sports train once or twice a

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

ay in their sports, but they do not exercise intensely more often t

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

han every 48 hours.

There is a difference between the good burning

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

of training and the bad pain of an injury. The good burning usually

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

affects both sides of your body equally and disappears almost immed

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

iately after you stop exercising. The bad pain of an injury usually

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

is worse on one side of your body, becomes more severe if you try t

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

continue exercising and does not go away after you stop exercising

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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Advice Pool - Hard-Easy Training Principle Applies to Any Sport or Fitness Program

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