Advice Pool - Health and Fitness

High Blood Pressure - Exercise - Risk of Death

Here's the simple truth - if you have high blood pr

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

essure then regular exercise will significantly prolong your life.

Moderate exercise is a critical

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

y important part of maintaining good health. People who are physically active are less likely than

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

their sedentary counterparts to develop chronic diseases such as diabetes, high blood pressure and

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

ther heart or cardiovascular disease.

There is a strong link between physical activity and death r

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

tes. In particular, physical activity is associated with a reduction in the risk of death due to he

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

art disease.

The amount of physical activity that you undertake will predict your risk of early de

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

th even if you have multiple heart risk factors or if you already have heart disease. (Risk factors

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

include having high blood pressure, diabetes, obesity, high cholesterol and smoking).

Many of us t

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

he the Western World have a high risk of heart disease because of our lifestyle habits and our body

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

weight.

Many good research studies show at most risk tend to be more sedentary. Could this be you

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

do you fit this description? If you do then for goodness sake do something about it .. Now!

A rec

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

ent research study looked at nearly a thousand American adults below retirement age. They followed

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

hese people for eight years and collected a huge amount of data about their health and their lifest

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

le.

The study found that those with risk factors for heart disease were about thirty percent more

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

likely to die than the rest of the population. They were also more likely to live a sedentary lifes

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

yle.

Taking regular light or moderate exercise reduced the risk of early death by a dramatic amoun

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

.

What's the message?

We should all be more active. If you have high blood pressure, are overweig

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

ht, have diabetes, a high cholesterol or are a smoker (or more than one of these risks) - then you

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

eed to increase your level of exercise ... and start now. Your life, quite literally, depends on it

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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