Advice Pool - Health and Fitness

We all know that well-balanced diets include the different nutrients we need to maintain health and well-being. But did you know that your exercise program needs to be well-balanced, too? There’s three types of exercise to include in your work-out diet.

Ae

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

robic Exercise

Aerobic exercise burns energy and oxygen, through continuous movement of the largest muscles in your body (your thigh muscles). Aerobic activities include bicycling, swimming, jogging, and (a great one for beginners or those who are recover

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

ing from illness) walking. If you’re just starting, try 10 minutes a day four days and increase as it feels comfortable until you’re exercising 30 to 60 minutes. Some people find that adding variety to their program (a new route every day; alternating classes

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

and stationary biking) keeps them motivated.

Finding the right pace for aerobic exercise is important. Rambling at too comfortable a pace may not maximize the benefits of aerobic exercising, but overdoing can make exercise “anaerobic” (non-oxygen burning). A

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

good way to make sure you’re exercising aerobically is to measure your heart rate. After exercising, put your fingers (not your thumb!) across your wrist (palm up). Count the number of pulses you feel during 10 seconds, then multiply that by six to convert it

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

to a one-minute heart rate. Keep your exercise heart rate to 55 percent to 80 percent of your estimated maximum heart rate (220 - your age)

If that’s too much math, you can estimate using the sing/talk test. While you’re exercising, carry on a conversation wi

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

th your gym-buddy or (if you’re exercising at home) sing a song (“Yankee Doodle” works well). If you feel just as you would if not exercising, pick up the pace a tad. If you’re out of breath and having to puff after each word, you’re no longer in the aerobic r

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

ange - cut back a bit to get the full exercise benefit.

Strength Conditioning or Weight-Training

Strength conditioning can include callisthenics, lifting free-weights, and machine-assisted lifting. Strength condition helps build muscles that can stabi

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

ize joints and may help prevent bone loss as you get older.

Strength conditioning seems to help weight loss. Conditioned muscle burns more calories even between aerobic exercise sessions. training seems to assist with retaining if you’re And if you’re on a

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

reduced calorie (weight reduction) diet, weight training may help you lose more fat and less lean muscle.

Some women are nervous about weight bearing exercise because they are afraid of getting “too bulky” or looking “too masculine.” Not to worry: men make te

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

tosterone in large amounts, which may contribute to that sort of muscular development; women generally don’t respond to strength training the same way and are more likely to lose inches as they work out.

Stretching Is Very Important

Stretching helps r

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

etain joint and tendon flexibility while you exercise. In addition, stretching may be an important part of recovery from a previous injury; your healthcare provider may recommend special stretches to part of recovery from an injury or stroke.

How To Stretc

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

h Safely:

Keep in mind that overstretching can increase your risks of being hurt during exercise. Here are some tips to help ensure that you are getting the maximum benefit out of stretching before or after exercise:

* Start gently. When you’re first sta

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

ting out, you may not be able to stretch your joints very far. Don’t push it or you may end up damaging your tendons, ligaments or muscles

* Stay gentle. The American College of Sports Medicine notes that the “no pain, no gain” method of stretching may destab

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

ilize your joints. Try a gentle stretch of the muscles you use for 10 to 30 seconds. If it hurts, there’s a reason.

* Match stretches to exercise. If you’re an avid dancer, make sure that your legs and ankles have been gently stretched; if you lift weights, s

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

tretch your arms and legs.

*Accommodate your history. If you’ve had a previous injury, make sure that your stretches accommodate rather than exacerbate it. Your doctor or a sports medicine practitioner can help you to finding the right stretches and will ofte

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

have handouts showing you how to perform them.

Remember, before starting any exercise program, you should consult with your health care practitioner to tailor it to your needs, particularly if you are 40, have existing health issues or a prior significant in

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

jury, or have suffered in the past from heart disease or stroke.

”Three things every exercise program should have,” American Council on Exercise 2001

Amisola, R.V. “Physical activity, exercise, and sedentary activity: relationship to the causes and treatment

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

of obesity.” Adolescent Medicine Volume 14, issue 1, pages 23-35 2003.

Cussler, E.C., “ Weight lifted in strength training predicts bone change in postmenopausal women.” Medicine and Science of Sports and Exercise , Volume 35, issue 1, 2003

Garry, J., “Physi

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

cal Activity and Exercise at Menopause,” Clinics in Family Practice, Volume 4, issue 1, 2002

Hobson, K. “The stronger sex. Women who lift weights get healthier, better bodies--not, new research shows, bulkier ones.” US News World, Volume 132, issue 16, p 52-5

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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