Advice Pool - Health and Fitness

There are many problems that can occur with our eyes, and most of the time if we look after them well enough, we can prevent any fu

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

ture problems. However, there are times when certain conditions creep up on you without you even noticing. One of these conditions

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

is Glaucoma.

So what exactly is Glaucoma?

Glaucoma is a really nasty group of eye diseases which sneak up on us and rob us of our

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

sight before we even know what has happened. The problem with Glaucoma is that it is not easy to detect it in its early stages and

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

often when it is detected it has already done irreversible damage. If any damage has been done to the sight due to Glaucoma, it can

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

not be restored and any loss of vision is down to the optic nerve being damaged.

Angle Closure Glaucoma

Otherwise known as Acute

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

Glaucoma, Angle Closure Glaucoma is rarer than Primary Open Angle Glaucoma and it happens a lot quicker too. Again, it occurs when

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

the drainage canals become blocked and the eye pressure rises really quickly.

The iris is not as open and wide as it should be wit

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

this type of Glaucoma, and the outer edge of the iris bunches over the drainage canals when the pupil enlarges too quickly or too

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

much. An example of this happening could be when you walk into a dark room.

Symptoms with this kind of Glaucoma include headaches,

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

nausea and eye pain.

There are other types of Glaucoma which are less common including Childhood glaucoma. This is usually found

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

in infants and children under the age of one. It is extremely rare and is usually inherited. It occurs when the drainage canal in t

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

e canal is incorrectly developed and it increases intraocular pressure which in turn damages the optic nerve. Symptoms for this kin

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

d of Glaucoma include cloudiness of the cornea and enlarged eyes.

Who is more at Risk of Glaucoma and how can it be treated?

Glau

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

coma can affect anyone at any age, though it is thought that people over the age of sixty are more at risk. Also Steroid users, peo

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

ple with diabetes and hypertension can all be contributing factors.

Treatment does vary and surgery is often the most common way o

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

restoring sight in the early stages of Glaucoma. For childhood Glaucoma, Surgery or medical treatments such as eye drops, may be u

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

sed. With Angle Closure Glaucoma, surgery is used to remove a small part of the iris to unblock the drainage canals.

So overall, t

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

he best advice is to have regular eye check ups, and if you do notice anything different, it is always best to get it checked out r

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

ight away. Catching Glaucoma early is essential so do not be afraid to book yourself an eye examination just to be on the safe side

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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Over the last few days we have discussed the Xbox 360 shortage extensively. We have told you that EB Games will not be caught up to pre-orders until the new year, that Future Shop has Xbox 360s left in expensive “bundles” and we have talked about how eBay sellers are making a killing online. Well there is another way of getting an Xbox 360 before Christmas, provided you are prepared to work for it. Today while perusing through my local Best Buy, I came upon a performance almost good enough for the big screen. A woman was standing in the middle of the electronics section, growing increasing agitated to the point where she actually started crying. At first I couldn’t tell what she was gong on about, but then I realized the source of the drama. The woman had come to Best Buy wanting to purchase a new Xbox 360 as a gift for her kid. But of course, the store was sold out days ago. Instead of accepting defeat and leafing, the lady told the electronics employee that she wanted the one on display. In a calm voice he explained to her that the display console was not for sale. That’s about when the “water works” started. I’m not just talking simple sobs; no, this lady was balling her eyes out and crying like a new born. After about 5 minutes of this, and the inevitable involvement of the store manager, the display was unlocked and the Xbox was carefully put back into a box and given to the devoted mother. What can we learn from this? Hissy fits work. So if you have exhausted all other possibilities and you still want your new Xbox 360, then we suggest you go to your local retailer and unleash a hissy fit like the world has never seen. Maybe, just maybe, you’ll get an Xbox.360.

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Advice Pool - Is Glaucoma Bothering You?

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