Advice Pool - Health and Fitness

Eye is an important and delicate organ of the human body. Any injury or infection to the eye may lead to serious complication

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

s and at times may result in blindness. In this article we will elaborate on the various factors responsible for eye infectio

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

ns, symptoms of eye infections and available treatment options.

Eye infections are caused by viral, bacterial or microbiologi

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

cal agent’s effect on the eye. The treatment option for eye infection depends upon the type and cause of such eye infection.

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

There are number of factors responsible for occurrence of eye infections and various methods are available for treating these

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

infections. Certain forms of eye infections are common and certain are rare.

Almost all people suffer from eye infection at

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

least once during their life span or know a person who has suffered from eye infection. People using contact lenses are consi

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

ered more vulnerable to eye infection, as constant wearing of lenses (without disinfecting) provide better place for bacterial

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

growth.

Belpharitis and pink eye are the most common forms of eye infections. Trachoma, which can spread easily, is another

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

common form especially in poor countries. Trachoma may lead to permanent blindness in some cases. Though most of the eye in

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

ections are mild in nature certain forms of eye infections can lead to serious complications and hence require immediate media

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

l attention. Any part of the eye (eye lids, cornea, optic nerves etc) can be infected by the eye infections. If you experien

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

ce or suspect occurrence of eye infection you must consult an ophthalmologist for timely and proper treatment.

Following are

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

some of the common signs and symptoms of eye infections.

Chronic redness of eyes
Frequent eye lid f

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

anking

Itching

Blurring vision

Discomfort of eyes

Watery eyes

Pain in

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

eyes

Eye discharge

Swollen eyelids

Swollen eye surrounding tissues

Follo

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

wing are some of the most common forms of eye infections.

Conjunctivitis also commonly known as pink eye

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

Blepharitis

Corneal Ulcer

Stye

Cellulitis

Trachoma

Treatment of eye infections

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

involves use of medications (eye drops). Personal hygiene plays greater role in prevention of eye infections. Certain dieta

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

ry supplements (colloidal) known for their characteristic of anti-bacteria can help in preventing and relieving eye infections

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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