Advice Pool - Health and Fitness

What causes dry eyes ? The cause of dry eyes is that the tear film (tear fluid) for some reason does not quite m

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

anage to keep the eye moist. Many factors can cause Dry Eyes Aging Environment factors such as weather and sm

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

ke Contact lens wearers (absorb lubrication and the tear film) Using computer and watch TV for long time Def

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

ciency in vitamin A A lack of sleep Some diseases may also lead to dry eyes

Dry Eyes Symptoms · Discomfort in

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

the eyes after periods of reading, watching TV, or using computer · Fell Itchiness · Redness of eye · Excessiv

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

tearing without relief · Feeling of presence of foreign object in the eyes

Dry Eyes and Contact Lenses Contac

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

lenses are manufactured from one of two types of polymeric materials. Soft contact lenses are made from hydroph

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

lic plastics that contain water. Rigid Gas Permeable Lenses are manufactured from polymeric materials that do no

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

contain any water all. Soft contact lenses and dry eye The new polymers used in these contact lenses help to k

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

ep it moist. There are 2 types of lenses formulated for people suffer from dry eyes, Acuvue Oasis and Proclear

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

ompatibles receive the most favorable reviews from wearers. Acuvue Oasis, by Johnson and Johnson, is specificall

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

y formulated for people who work or live in dry environments. Acuvue Oasis contains Hydraclear Plus a special re

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

etting agent that's make the contact lens feel moist Proclear Compatibles, by Cooper Vision, is made from omafil

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

on A, Proclear lens contains phosphorylcholine - a substance that occurs naturally in human cells (Proclear uses

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

technology of biocompability) that makes your body not reject it as a foreign object in your eye So Proclear Co

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

patibles feel moist in your eye and don't cause dehydration.

RGP lenses for people with dry eyes RGP lens is m

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

de from polymeric materials and don't contain any water. So water won't evaporate from the surface of the lens as

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

with soft lenses. That is why some doctors recommend their patients with dry eyes to wear RGP contact lenses.

Pr

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

blems of RGP Lenses It can irritate your eye if there are not enough tears under it

If you have dry eyes and y

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

ur current contact lenses don’t feel comfortable. Ask your doctor if the lenses he recommended would work for you

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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