Advice Pool - Health and Fitness

Helpful Hints for Vision Injuries

• People sometimes ignore changes in their vision, hoping it will go away. Flashing lights, a flood of new floaters, a spider web on the ed

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

ge of the visual field all seem like minor annoyances but may be symptoms of serious problems that could lead to permanent vision loss.

• You should immediately seek medical

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

care if you have double vision, vision loss, eye pain, colored circles around lights, new spots, strings, cobwebs, shadows before the eyes, bulging of the eye or swelling of e

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

ye tissues, sudden crossed, turned or wandering eye, discharge, crusting or excessive tearing, eyelids stuck together, sudden and persistent blurring or flashes of light.

• T

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

here are certain warning signs of a potentially serious eye injury. These include tears in the outer ocular walls, bleeding on the surface or inside the eye, vision loss and/

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

or a foreign body lodged in the eye. You should not try to remove a lodged foreign body in the eye without professional assistance. The risk of further injury is great.

• P

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

rompt first aid after one of these types of injuries may greatly improve the chance of preserving vision. The first step is to place a protective cover over the eye to prevent

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

further damage. Then seek emergency care as soon as possible.

• The type of treatment given depends on the injury. Surgery may be required to repair blunt or penetrating inj

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

uries. Any suspicion of a penetrating injury to the eye requires immediate evaluation by an ophthalmologist or in an emergency room.

• If you have severe eye pain, you need

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

to be evaluated by an ophthalmologist or an emergency physician immediately. Simple corneal injuries are treated by removing any foreign material and covering the eye with a p

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

atch to let the cornea heal. Antibiotic drops or ointments are often used to prevent infection. They may also be prescribed until a corneal abrasion has healed. Rest and pat

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

ching the affected eye may help. You should avoid driving and other potentially dangerous situations while the eye is patched, since depth perception is altered. Call for an

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

ambulance or take a taxi. You may need drops at the ER that affect your vision and which will prevent you from driving home from the hospital.

• Chemical burns from acids or

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

alkalis splashed in the eye are dangerous. Many household chemicals are strong acids or alkalis. Drain and oven cleaners or other caustic products or concentrated acid produc

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

ts are particularly dangerous. You should immediately flush with tap water or any drinkable liquid for 30 minutes, and then rush to the nearest emergency facility. Flush bef

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

ore you call the hospital. Do not try to neutralize the chemical.

• If you have been struck in the eye, gentle icing with crushed ice is helpful to reduce pain and swelling.

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

If there is severe swelling or bleeding, loss of vision or double vision, see an eye doctor immediately. Do not blow your nose since bacteria from the sinuses may be blown

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

into the tissues around the eye, causing eye infection. This is applicable in cases of socket fracture. Do not rub or apply pressure to the eye. Protect the eye with a pap

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

er covering or patch on the way to medical care.

• People seldom think to seek treatment for a black eye. If you've been in a fight or gotten punched in the eye, even if it

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

doesn't seem so bad and you put ice on it, you should see a doctor. The bone around the eye may have fractured, or other tissues and nerves may have dislocated from the force

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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