Advice Pool - Health and Fitness

Do you find yourself not as happy when you look at yourself in the mirror while fixing your hair? Have you even gone as far as, or is considering shaving your head to avoid the embarrassment? I understa

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

nd how you feel. I have been in this situation countless times. I began losing my hair when I was 27. It was a gradual thinning out on the crown (top) of my head. The feeling I had at the time was low

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

elf-esteem. I felt like every time I looked at girl, she was noticing my hair loss and not me. Trust me; it is not a good feeling. Of course, there were woman who said they didn’t notice or didn’t care,

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

but in my mind, they did care and were just being nice. Let’s be honest, I know I would care. It is only natural to notice and everyone has an opinion.

As a result, I decided to fight my hair loss. Of

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

course, there are many hair loss products out there that are nothing more than “snake oils”. However, there are many products I have tried over the past 8 years and surprisingly, some of them do work. H

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

wever, it takes patience --to see the results and persistence-- to keep up the routine. If you don’t keep up the daily routine, you will begin to lose any hair re-growth or hair that was maintained. I’m

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

now 35, I have the same amount of hair I had when I first started losing it. I’ll be honest, I have gone through phases of being lazy and not keeping up the daily routines, but I never went long enough

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

where I had begun to lose more hair than I had gained or maintained. The toughest part was keeping up the routine of applying the topical solutions two times a day. I learned that if you discipline you

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

self, you really can results.

Below I list the products that were successful and the products that were not successful. Keep in mind, as I begin to list the products below, everyone is different and th

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

ere can be different response times for each person.

The successful products:

• Follicare – Contains the scalp treatment shampoo, 5% minoxidil and the all- natural DHT blocking pills. I took this prod

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

ct for 2 years and it worked very well for me. I had some regrowth and the thin hairs on my crown became thicker again.

• Avacor - Contains the scalp treatment shampoo, 5% minoxidil and the all natural

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

DHT blocking pills. Like Follicare, I took this product for about 2 years and it worked very well for me. I had some regrowth and the thin hairs became thicker again. I would almost think these two prod

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

ucts are the same, except some difference in the ingredients of the all-natural pills.

• Xandrox 5% or 15% - This is the most effective product so far, in terms of topical solutions. This contains 5% m

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

noxidil / 5% azelaic acid solution for the treatment of alopecia androgenetica. In layman terms, it means going bald. Xandrox has been proven effective in limiting DHT (the leading cause of hair loss in

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

50 million men and women) right in the scalp. The DHT can strangle the hair follicle in the shaft and Xandrox can combat the DHT. However, like Minoxidil, it must continually be re-applied in the mornin

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

g and night. I like the 5% Xandrox, due to the fast drying effects (usually within 1-2hours) and it leaves the hair looking thicker after it dries. However, there are now more powerful versions on the m

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

rket. To learn more about Xandrox, go to www.adviceonhairloss.blogspot.com

Non-successful products:

• Hair Genesis – I tried this product after seeing countless infomercials late a night about it. It

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

ffers the traditional shampoo, all natural DHT blocking pills (2X a day) and minoxidil 5%. I found this product, for whatever reason, was not as effective as other products with the same combination.

•

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

Laser Comb – The laser comb did not produce any real results for me to notice. I still continued to lose my hair.

• Nioxin Shampoo and Scalp Treatment – This shampoo left my hair feeling very soft and

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

had tingly cool feeling afterwards for about 5-10 minutes. The feeling of my hair felt good. However, I did not notice any effect on my hair, if used without some type of topical solution with minoxidil

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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