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  • Advice Pool - Foods That Naturally Reduce Cholesterol

    What is Cholesterol?

    Cholesterol is a wax-like substance that is present in the cell membranes of body tissues and is carried in the blood plasma. It is a sterol; a combination of alcohol and steroid and is also called atherosclerotic plaque. The body requires choles
    According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product
    terol in order to form and sustain cell membranes, help with the production of bile and aid the metabolism of fat soluble vitamins.

    Over time, cholesterol builds up on the artery walls and this condition is known as atherosclerosis. Atherosclerosis was thought to be an affliction of the elder
    ; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

    Examples of combination products may in
    ly until the 1950’s when American pathologists were sent to Korea by the Pentagon to study the bodies of servicemen who died during the conflict. They autopsied around 2000 soldiers and found that approximately 75% had waxy, yellow deposits on the walls of their arteries; a shocking statistic
    lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

    considering the average age of the soldiers was 21. Their findings astonished the scientific community as it highlighted the onset of heart disease in the very young.

    LDL and HDL Cholesterol
    There are two different types of cholesterol; low-density lipoproteins (
    here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe
    DL) and high-density lipoproteins (HDL). HDL is commonly known as ‘good’ cholesterol and LDL is recognised as ‘bad’ cholesterol. LDL has been markedly linked with heart disease, whereas HDL is thought to reduce the chance of a heart attack. It has been estimated that approximately 25% of Amer
    d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

    Combination pro
    icans are at risk from heart disease due to atherosclerosis, and around 10% have such high levels that doctors are left no choice than to prescribe cholesterol reducing drugs.

    Foods that Lower LDL Cholesterol
    There are a number of foods which are believed to signi
    ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc
    ficantly lower LDL cholesterol. Fiber-rich foods are said to be particularly beneficial and will not only lower ‘bad’ cholesterol, but also help the bowel to function properly, lowering the risk of colon and bowel cancer. There are many other foods that can help the body fight back against t
    easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi
    hese dangerous deposits.

    • Fiber-rich foods, particularly oat bran, barley and wheat bran. They can be eaten as a cereal for breakfast and sprinkled onto other foods. Pearl barley can be added to soups. Apples and pears also have c
    nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically
    nsiderable amounts of soluble fiber and should be enjoyed on a daily basis
  • Beans and pulses are high in fiber and low-fat. They also contain lecithin, a nutrient that lowers cholesterol. Try to incorporate kidney, fava, borlotti and other d
  • and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ
    ried whole-foods into your diet; there are many different types of lentils and pulses that are delicious in soups and stews
  • Avocado contains prolific amounts of monounsaturated fat, which helps to reduce LDL cholesterol and has many other h
  • ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi
    ealth benefits including anti-cancer properties
  • Raw carrots are rich in a fiber called pectin that is renowned for minimizing cholesterol. There are a number of fruits that also contain pectin, including; apples, citrus fruits, strawberries, raspberries and other re
  • ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

    Following aspects would a
    d or black berries
  • Shitake mushrooms are widely used by the Japanese and include a compound called lentinan, which not only lowers cholesterol, but is also thought to be anti-cancerous and may help to boost the immune system
  • Garlic is a sup
  • dd to the challenges in developing combination products:

    Which markets to tap where the combination products can do fairly well?
    Which combination prod
    r food and is well known for its blood-thinning properties. It also contains a substance allicin which is thought to prevent the body retaining LDL cholesterol and research has shown that the equivalent of one clove per day can lessen ‘bad’ cholesterol by 10-15% in the majority of people
    cts are meaningful and rational?
    Which therapeutic categories to select?
    Which Combinations can address unmet needs of the patients?
    Do combin
  • Root ginger has been used in Chinese medicine for centuries and has numerous health benefits. It can be added to stir-fry’s (using healthy sesame oil) and other vegetable dishes
  • Nuts are naturally high in omega-3 fatty acids a
  • tions increase the patient compliance?
    What would be the developing cost?
    How to tackle the risks encountered during combination product developmen
    nd are known to significantly reduce blood cholesterol; walnuts, pecans, hazelnuts and almonds are especially beneficial
  • Sesame seeds are rich in phytosterols. These compounds are said to substantially lessen LDL cholesterol. Other foods containing
  • t?

    As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel
    phytosterols include; celery, lettuce, asparagus, spinach, tomatoes, ginger, squash and strawberries
  • Safflower, canola, soybean, and olive oil are monounsaturated and are an excellent source of omega-3 fatty acids. Research indicates that they can d
  • ping new procedures for reviewing their safety, efficacy and quality.

    Professional from academic institutions, pharmaceutical industries, health care indust
    crease atherosclerotic plaque by up to 15% when eaten regularly
  • Salmon, tuna, sardines and mackerel contain considerable amounts of omega-3 fatty acids, which have many health benefits and are essential for brain and eye function
  • Prunes ar
  • y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products
    e a wonderful source of antioxidants and fiber, which is known to reduce LDL cholesterol
  • Alfalfa sprouts contain a substance called saponin, which is thought to obstruct and inhibit the formation of atherosclerotic plaque in the arteries



  • If you have hi
    .

    As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de
    gh cholesterol or a family tendency towards atherosclerosis it is best to avoid processed and prepared foods, fried food, food containing animal fats or animal products, high-fat dairy products and food containing either saturated fat or trans fats. Research has revealed the k
    elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

    Companies that provide selfless information through particip
    ey to lowering LDL cholesterol is a healthy, balanced diet that incorporates plenty of soluble fiber and at least five portions of fruit or vegetables a day. This combined with regular cardiovascular exercise should help keep the heart healthy and provide numerous other health benefits as well


    tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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