Advice Pool - Health and Fitness

If you or a loved one has heart disease, heart attack prevention and treatment are very important subjects. Your physician may have recommended taking a low dose aspirin each day to avoid heart attack. You may have heard that you can increase your chances

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

of survival during a heart attack by taking aspirin. But how?

How Can Aspirin Help in Heart Attack?

Imagine that you are sitting watching TV with your spouse. You begin to sense that your chest is heavy. It feels as though someone is tightenin

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

g wide steel bands around you. You shift positions, but the feeling remains. You take a few deep breaths and try to relax, thinking it is stress. The pain begins to spread to your jaw and shoulder. You mention it to your spouse, who turns to look at you,

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

ashes to the phone to call for an ambulance, and returns with an aspirin. "For your heart attack," says your spouse. Why?

How can aspirin help in heart attack?

Heart Attack Scenario

A heart attack is an active, ongoing event. It is not something

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

that begins and ends in five minutes. You can limit the damage done to your heart and body during this ongoing event by taking action immediately after the heart attack begins. Calling emergency services is one action step. Taking aspirin is a second act

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

on step.

Paramedics will arrive quickly when you call 911. They will give you oxygen and medication for your heart attack. They will monitor your blood pressure and heart rhythm to try to prevent heart attack complications. They will rush you to the emer

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

gency room of the nearest hospital.

Once you reach the Emergency Room, doctors and nurses will hurry to perform an EKG and blood tests to confirm or refute a heart attack diagnosis. If you are having a heart attack, doctors will usually try to open the b

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

locked artery with angioplasty, a stent, or a drug.

But why take aspirin? If they are going to use all of these modern "miracle-workers" on you, how can aspirin help in heart attack?

Aspirin's Role

Aspirin has been found to slow down platelets.

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

latelets are microscopic blood cells your body uses to trigger blood clotting. If you cut your finger, blood begins to flow from the cut. Immediately, platelets move to the cut finger and cause the blood to clot. If you were to take aspirin the moment you

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

cut your finger, you would slow down the movement of platelets. The blood would continue to flow freely for a longer time. You would need only a tiny amount of aspirin to slow down every tiny platelet in your bloodstream. You would have to take it quic

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

ly, though. The clotting of blood would increase minute by minute, so the sooner you took the aspirin, the better your chances of keeping the finger bleeding.

Of course, this would be foolish action in the case of a cut finger. You want the finger to sto

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

p bleeding. You want the blood to clot.

In heart attack, however, you do not want the blood to clot. The reason for most heart attacks is the rupture of plaque in a coronary artery. When the rupture occurs, the body senses injury and calls for platelets.

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

The platelets hurry to trigger a blood clot, just as they will in a cut finger. As minutes pass, the clot grows larger and larger. It grows until it completely blocks the artery. Blood can no longer flow to the part of the heart served by that artery. Bl

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

od can no longer carry oxygen to the heart. Without oxygen, that part of the heart begins to die. The heart attack runs its course.

If aspirin is taken in the first few minutes of an attack, you slow down the rush of platelets, just as in our example of

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

the cut finger. You make it more difficult for the blood to clot. You keep the blood flowing, carrying vital oxygen to the heart. You limit the risk of heart attack damage.

How to Take Aspirin for Heart Attack

1. QUICKLY: The most important thing

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

is to take aspirin immediately if you sense you may be having a heart attack. Aspirin needs nearly 15 minutes to fully slow platelets. Get it into your blood stream quickly.

2. AMOUNT: Take one 325 mg. of aspirin for heart attack. Do not take two or thre

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

e in hopes of getting better results. A smaller dose is actually more helpful than a larger dose.

3. TYPE: The aspirin must not be enteric-coated. The coating is added to keep aspirin from dissolving too quickly in your stomach. For heart attack, you wan

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

t it to dissolve as quickly as possible. Even when chewed, enteric-coated aspirin have been found to dissolve too slowly. So be sure you always have at hand non-coated 325 mg. aspirin tablets.

4. CHEW: It is very important that you CHEW the aspirin. Do n

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

t swallow it whole. CHEW the aspirin at least 30 seconds before swallowing it. Chewing will reduce the tablet to small particles, ready for digestion. It will also stimulate saliva, which will start the digestion. CHEW.

In the October 1997 issue of "Circ

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

ulation," the American Heart Association (AHA) journal, it was reported that up to 10,000 more people annually could survive heart attack simply by chewing one 325 milligram aspirin tablet at the first chest pain or other heart attack symptom. Be prepared

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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The purpose of the Delivery Phase is to design, develop, test, implement and hand over the solution identified in Phase 2, the Feasibility Study Phase. Project Progress Reports are mandatory for all projects regardless of size.

Substantial opportunities for increased sales and profits are missed by not seeking out and implementing joint ventures. Strategic alliances also create value for the customer and save money and bui...

In all that we see in nature, the principle that we usually see is that form follows function. This is because in almost all creatures and plants, the unique features that they have serve a purpose. One example of this includes how some creatures are able to camouflage themselves within their background because their skin color allows them to do so. Other examples include birds with specially shaped beaks to help them catch prey, and the woodpecker is a good example of this. However, this principle does not only apply to the physical attributes of animals and plants as this principle is also followed up to the molecular level. This is seen on how the structure of the most basic genetic molecule, which is DNA also follows this principle.

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