Advice Pool - Health and Fitness

Garlic gets its name from the old English ‘gar’ meaning spear (referring to it’s spear shaped leaves) a

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

nd leac from leek. So spear-leek would be the rough translation from the old English.

Botanically garl

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

ic is in the allium family making sense of the second syllable of its name, leek (leac), which along wi

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

th the onion also belong to this group of pungent plants.

History:

Garlic is thought not to have evol

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

ved in the wild but from cultivated Allium longicupis or Wild Garlic, which does grow naturally in cent

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

ral Asia.

Cultivated garlic was used in Ancient Mesopotamia and Egypt from at least 2000 BC.

It has b

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

een found in Egyptian tombs as an ingredient used in embalming and as an offering to the gods. The Gree

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

ks and Romans saw garlic as a food that would give strength and workmen and soldiers would use it. A do

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

cumented Roman hangover cure includes 16 bulbs (not cloves) of garlic boiled in a bucket of wine, mmm l

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

ovely.

Nutrition:

Garlic has been known to, ‘thin the blood’, much in the same way as fish oils. It c

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

an help in lowering blood pressure and evidence is building in its use in lowering blood cholesterol le

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

vels.

Growing Garlic:

Garlic is one of my favourite herbs and has to be one of the easiest things

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

that I have grown.
• Buy a garlic bulb (also know as head) from the supermarket, greengrocers or

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

market and plant each individual clove about 5cm (2inches) down and 15cm (6 inches) apart.
• Garli

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

c grows best in hot wet conditions, but try it all year round. (I have only tried in the spring digging

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

up in the summer, but am told that it can grow all year round.
• Ensure that the growing area is

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

weed free.
• Garlic likes water, so if you live in a hot climate you may need to water it a fair

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

amount. Just don't let it dry out is the common sense approach.
• After about four months you shou

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

ld have some lovely strong garlic, you can tell it is ready when the foliage dies down
• Dig up wi

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

th a fork to avoid damaging the bulbs.
• Does best when the soil pH is in the 6.2 to 6.8 range.

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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