Advice Pool - Health and Fitness

Many people have problems falling asleep at night, often because their minds keep running at full-speed even though they feel physically tired. I used to have p

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

roblems falling asleep at night, but now I'm out within minutes - maybe even seconds - of the light going out. Here are six techniques that have helped me get t

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

o that point:

1) Keep a regular sleep schedule. This gets your mind and body into a routine. My light goes out somewhere between 9:45 and 10:15 pm almos

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

t every night. I know that may seem ridiculously early to some of you, but up here in northern New England people seem to go to bed and wake up earlier than oth

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

r places I've lived.

2) Stay away from reading fiction before bed. I love a good novel, but fiction stimulates your imagination and does not help you re

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

lax your mind and get to sleep. Before I adopted this practice, I can't tell you how many times I'd stay awake late to finish a chapter or even a whole book. An

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

d then my mind would still be thinking about the book after I turned off the light. Now, I pick nonfiction instead. Yes, nonfiction can be interesting, but it r

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

arely gets my mental energy going like a good thriller. Mental energy is not what you want when trying to fall asleep.

3) Take a few minutes to quiet your m

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

nd. This will help stop that ceaseless thinking. Ways to quiet your mind are: slow and deepen your breathing; think of a few things that went well with the

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

day and be grateful for them; release the emotions attached to anything that didn't go well; stop consciously thinking about things. That last one means to stop

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

trying to think about any issues you have, and stop consciously putting your attention on them. If something is still on your mind, write it down on a notepad

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

next to the bed and resolve to deal with it tomorrow. This is really an important step because if you haven't released something that's bothering you before you

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

try to go to sleep, you'll be replaying it over and over unless you have extremely good control of your thoughts.

4) Keep away from any form of caffeine aft

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

er 1:00 pm in the afternoon. No coffee, decaf, tea or soda with caffeine. If you are susceptible to the effects of caffeine, it will make it harder for you

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

to quiet your mind when you want to sleep. If I have a Coke at three in the afternoon, I'll feel tired but unable to sleep until midnight. (Another note: I can

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

also always tell if there was MSG in my Chinese dinner because my heart will be thumping and I'll be wide awake staring at the ceiling at 1 am.)

5) Focus on

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

your body and relax one area at a time starting at your feet. This both helps your body physically relax and helps you keep your attention on something othe

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

r than your to-do list, what's going on at work, how mad you are at someone, etc...

6) Visualize walking down an endless stairwell. Keep your attention

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

on your feet as you visualize your walking. This is similar to number 5 above. Giving your attention to something mindless and repetitive helps your brain shut

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

down.

Those are my tips for how to fall asleep quickly at night. They work for me, and if you have a sleep problem, I hope that maybe they can work for you too

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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