Advice Pool - Health and Fitness

Most people snore sometimes, if not all the time. Some snore loudly, some just purr. Surveys have produced different results, but it is probable that about half

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

of us over the age of 30 snore. The probability of snoring increases with age and obesity and about 60% of men and 40% of women do it regularly, even more do it i

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

nfrequently.

Snoring is caused when there is an obstruction to the free flow of air in the back of the throat and or nose. This area is 'collapsible', so the noi

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

se is usually produced by the flapping of the uvula against the soft (upper) palate. Therefore, weak throat muscles or a 'fat neck' can aggravate the condition.

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

Consumption of alcohol in the late evening increases the chances of snoring because it relaxes the throat muscles and sleeping on one's back allows the tongue to s

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

lip back and partially block the airway. Also, not everyone is built to exactly the same proportions - some have a longer, narrower palate, which is more collapsi

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

ble and others have a longer uvula, which is more flappable.

Some say wearing a ring on one of the little fingers helps because it puts pressure on a relevant acu

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

uncture point. Others put a tennis ball in a sock and sew the sock to the back of their pyjamas. One doctor even suggested that playing the didgeridoo could cure

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

snoring by tightening up and toning the throat muscles.

Drinking less the evening, losing weight and sleeping on your side are the best 'home' remedies. However

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

, there are also surgical appliances on the market and surgery is available too. The appliances vary, but they range from adhesive strips to hold the nostrils ope

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

n to 'mandibular advancement splints', which, worn in the mouth, 'set the jaws to their optimum position' [!].

Snoring can cause serious social, psychological, ph

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

ysical and medical problems and should not be taken too lightly. Socially, families may suffer from having a heavy snorer in the household. Friends and colleague

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

s may not invite a heavy snorer to 'sleep over' or go on holiday or on business trips together. Psychologically, a snorer may feel ostracised, embarrassed or even

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

victimized for something that is really totally beyond his or her control. Physically, snorers suffer from lack of sleep and all that that entails; for example,

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

aytime drowsiness and the inability to concentrate for log periods of time, which in turn can cause problems at work and in the car - a high proportion of road acc

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

idents is caused by the driver dozing at the wheel. Medically, a recent Australian survey reported that, after treatment, heavy snorers were 64% less likely to su

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

ffer a heart attack or stroke, because heavy snoring, which can also be sleep apnoea, puts extra stress on the heart. Obstructive apnoea is the condition where a

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

snorer stops breathing due to complete obstruction of the airway for up to ten seconds seven times an hour while sleeping. This can happen between 30 and 300 time

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

s a night. After years of apnoea, hypertension and an enlarged heart may result.

Light snoring is not necessarily serious but even that means obstructed breathin

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

g, which is not a good thing. Heavy snoring can be a sign of a problem or a warning of problems to come. A doctor can help; snoring is neither funny nor hopeless

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

HTTP = HTML link (for blogs, profiles,phorums):
<a href="http://www.advicepool.org.ua/article/266147/advicepool-Snoring-Why-Do-We-Do-It.html">Snoring: Why Do We Do It?</a>

BB link (for phorums):
[url=http://www.advicepool.org.ua/article/266147/advicepool-Snoring-Why-Do-We-Do-It.html]Snoring: Why Do We Do It?[/url]

Christmas is arriving. Santa Claus is going to come again with his reindeers on a sleigh. It is party time once again. Celebrate this Christmas with full zeal and in all the splendour with your family members with Christmas loans. Give them the Christmas they will remember for the rest of their lives but all at a very low cost without expensive credit cards and overdraft facility.

Writing content for an information-rich site can be time-consuming and tedious, especially if you're not a born writer. But there are many ways you can add substantial content to your site by using other people's content.

The world is changing fast. It's more important than ever to get your kids interested in science at an early age. And it's easier than you think. Find out how with these great tips on turning everyday activities into fun learning experiences.

Tags

Links

Advice Pool - Snoring: Why Do We Do It?

Related Articles: