Advice Pool - Health and Fitness

Vitamin C prevents many a debilitating diseases and increases the body’s imm

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

unity. This vitamin can be taken with or without food. In general, about 500

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

mg is needed every day for general health requirements. If your health requi

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

rements need more than 1,000 mg, it must be split across multiple doses thro

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

ghout the day.

Other than through medical supplements, some excellent Vitam

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

in C Sources include parsley, broccoli, bell pepper, strawberries, oranges,

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

emon juice, papaya, cauliflower, kale, mustard greens, and Brussels sprouts.

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

This particular vitamin is naturally excreted by the body when in excess. S

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

me mammals can use their own body cells to create it. The vitamin content i

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

n food varies significantly. It is highest when a fruit is ripe and younger

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

t the time of harvest. In order to retain the vitamin in foods during prepar

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

tion, cooking or storage, fruits and vegetable must be served raw whenever p

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

ossible. Prepared juices must be refrigerated and should not be stored for m

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

re than 2 to 3 days. Cut fruits and vegetables must be stored in airtight co

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

ntainers. Most cereals are fortified with Vitamin C. The ready-to-eat cereal

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

contain at least 25 percent of the US RDA for Vitamin C.

When looking out

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

for Vitamin C supplements in the store, take special care to watch out for p

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

sterified C, time-released C. It has not been scientifically proven that the

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

se can be absorbed easily as compared to ascorbic acid. And remember, vitami

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

C is only valuable when taken as a supplement to an all around healthy diet

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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