Advice Pool - Health and Fitness

For most people facing obesity and morbid obesity the first line of attack will be for their doctor to recommend a strict program of both diet and exercise.

Millions of peo

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

ple across the world are dieting at this very moment. Indeed, in the United States alone, it is estimated that one out of every three adults is currently on some form of die

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

t. For many dieting will succeed in the short term but, for the vast majority of people, not only will any weight lost be regained but many will end up weighing more than be

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

fore they started their diet.

So why do so many diets fail?

We live in an age in which speed is all important and we want whatever we want right now and not tomorrow or ne

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

xt week. Dieting is no exception and most people want to see rapid results and so set themselves unrealistic goals such as losing twenty pounds in a month. When this doesn't

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

happen they then simply blame the diet and either give up altogether or move on to another diet with the same results. Trying to lose weight steadily at about one or two po

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

unds a week is fine but anything over this is simply not sustainable in the longer term.

The next problem for many dieters is that they fail to organize their social life a

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

round their diet. Now it's not being suggested here that you should put your social life on hold while you're dieting but abandoning you diet once a week for your Friday nig

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

ht dinner with friends is not going to work. By all means continue to enjoy a full social life but include whatever you're eating and drinking as part of your diet plan. Thi

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

s might mean substituting fresh fruit for your usual baked Alaska but that's the price you're going to have to pay if you want to lose weight.

Another problem for many diet

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

ers is that dieting can be expensive and take a surprising amount of effort. Most diets are also boring. Preparing diet meals often means buying healthy food alternatives, w

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

hich are not always easy to find and can be expensive, and then spending a lot of time preparing a meal which often leaves you wondering if it was worth the effort. The limi

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

ted choice of foods available for many diets also means that you soon get tired of eating the same old thing every day.

Yet another difficulty which most dieters encounter

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

is that of calculating both the calories they are eating and the calories they are burning up through exercise. It is not at all uncommon to underestimate the former and ove

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

restimate the latter.

This is all well and good and is probably enough in itself to show why most diets fail. However, all of this pails into insignificance alongside the r

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

eal reason for the failure of most diets.

The majority of dieters set out on their diet with the best of intentions and many will research their chosen diet thoroughly and

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

even draw up a detailed and comprehensive diet plan. In nine cases out of ten however these plans are simply too complicated and dieters don't stick to them!

Dieting is not

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

rocket science. In fact dieting is simply a matter of reducing your intake of calories and burning off calories through exercise. If you put together a simple plan to do ju

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

st that and don't rush things but take your time and lose weight at a pound or two week you'll be surprised just how easy dieting is.

Forget Weight Watchers, the Atkins die

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

t and all the other money making diet products out there and simply cut down on your calorie intake and exercise a little more and, in time, you'll shed those excess pounds.

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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