Advice Pool - Health and Fitness

The middle-aged spread. The beer gut. The spare tire. The pot belly. Love handles.

In the end, let’s just call i

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

t what it is: FAT. It doesn’t deserve a cute name.

As we age, we tend to put on weight, especially around our mi

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

sections. This is linked to various factors, including an age related loss of muscle mass, which can be reversed

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

with training, and an increase in the tendency to form fat, which cannot.

All of us have a genetic tendency tow

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

rds fatness or thinness. Fat or thin, we also have a natural tendency to deposit fat in one area of the body or a

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

other. Some of us put on fat around our waists: the “apple” shape. Others of us put on fat on our backsides and t

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

highs: the “pear” shape. Men tend to be apples, women tend to be pears, but there are plenty of male pears and fe

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

ale apples out there.

Even for those of us who are in a healthy weight range, the concentration of fat around ou

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

r mid section has been shown to increase the risk of Type II diabetes (see below) heart-attack, high blood pressu

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

e and strokes. Abdominal fat not only ruins your figure, it ruins your health.

One way to determine if you’ve go

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

too much fat around the middle is to calculate your waist-hip ratio. This is a simple ratio of the measurement o

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

f your waist at its narrowest point divided by the measurement of your hips at their widest point.

For women, th

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

s ratio should be less than 0.8. For men, less than 0.95.

Over this ratio, there is an increased occurrence of h

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

eart disease.

One study showed that men under 40 with no symptoms or outward signs of heart disease who had a hi

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

h waist-hip ratio had more plaques in their coronary arteries. The same was found in women under 50 in another, s

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

milar study.

So pull out your measuring tape, and trade your apple for a pear!

Remember: a pear a day keeps the

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

doctor away!

Type II Diabetes

Type II, or Adult-onset diabetes, is an imbalance between the body’s ability to

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

roduce insulin and the body’s need for insulin. When we are overweight, we have more cells that require sugar, an

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

d our capacity for producing insulin is usually limited.

Losing weight can help control diabetes to the point wh

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

re no medications may be necessary. Many Type II diabetics require some oral medication, and some require insulin

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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As we age, we are more susceptible to gaining excess fat in the midsection. The best way to tone the abdominal area is to decrease your caloric intake, practice good posture, and exercise. Regarding exercise, there are many of the best abdominal workouts that you can perform to get your abs in shape.

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