Advice Pool - Health and Fitness

The papers are full of it, the TV won’t stop going on about it and your belly hanging over your waistband justifies it! It’s

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

time to lose weight - but how? There are so many gimmicky diets out there, not to mention 'potions and pills' that w

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

ill help you shift the weight, BUT you also know from experience that the pounds will pile right back on again the moment

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

you stop. So the question is "how can I lose weight permanently?"

These ‘no nonsense’ top 10 weight loss tips tell you

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

how:

1. Eat less and/or exercise more than you have been – in other words you do need to create a calorie de

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

ficit in order to burn more calories than you consume in a day, BUT…

2. Do not starve. You will NOT lose fat if yo

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

u starve yourself. Most people need only to drop their total calorie intake by 300 kcals a day – some by more and some by less

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

– it just depends what the base-line or starting point is – and it often helps to have someone work that out for you!

3. E

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

at when you are hungry and stop when you feel satisfied. It sounds simple – and it is!

4. Eat real food – not powd

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

ered drinks as meal replacements. The process of digesting real solid food actually stimulates the metabolic rate. This is cal

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

led the 'thermic effect' of food, which cannot be achieved by liquid food or supplements.

5. Be consistent with your exerc

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

ise which should involve aerobic activities and some kind of resistance training

6. Get your diet 'nutritionally' in orde

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

r, and your exercise before complaining that it’s your genes, you have 'big bones' or that you have 'a slow metabolism'! S

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

ound nutritional practice and effective exercise is a very powerful combination indeed, and if it’s fast permanent results

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

you want – then this is what you need to focus on.

7. If you want to lose fat permanently you need to put in some effort and

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

be somewhat self-disciplined. You are the only person you are with 24 hours of every day!

8. STOP looking for short

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

cuts to lose weight.

9. Your aim is to lose fat, not muscle and water. Anything that promises fast weight loss, will

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

give you fast fat gain when you start living normally again! You are aiming to lose 1-2lbs a week, with a combination of e

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

ffective eating and exercising.

10. Finally, don’t believe everything you read in magazines. If it sounds too good to be t

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

rue – it probably is! _____________________________________________________________________________________

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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