Advice Pool - Health and Fitness

What if I told you that fat is a major contributor to the increasing problem of obesity in the world today. It’s stored in the fat cells of the body.

The number of f

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

at cells is estimated to be around 50 billion for the average person. It can be up to 100 billion for the obese person.

Fat cells are like storage tanks of energy to

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

be used for later use. It has been shown that obese people who binge eat may stimulate baby fat cells to sprout to increase the number of fat cells they have.

Fats a

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

e found in foods such as butter, margarine, oils, fats, dripping, nuts and oil seeds.

Research conducted indicates that good fats such as fish oils especially deep s

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

a fish, olive oil, canola oil, avocado and nuts contain important fatty acids which if taken by people aged 65 plus reduced the risk of a fatal heart attack by 44%.

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

Other names for fats include… Lard, animal shortening, coconut oil, palm oil, vegetable oil, butterfat, whole milk solids, copra, tallow, chocolate chips, shortening,

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

margarine, cocoa butter.

Lets have a look at the different types of fat. There are three types of fat to found in the diet:

Saturated fats - are found mainly in ani

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

al products and do the most damage and are the most related to the build-up of cholesterol in the arteries.

Research has indicated that saturated fats in the diet ca

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

increase LDL cholesterol levels in the blood, which is the unwanted cholesterol and should be avoided. The following foods contain this type of fat:

· Meat
· D

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

airy
· Eggs
· Cakes, biscuits and pastries

Monounsaturated fats - Monounsaturated fats help to decrease the cholesterol and LDL levels in the blood. The fo

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

lowing foods contain this type of fat:

· Olive Oil
· Canola Oil
· Peanut Oil

Polyunsaturated fats - Polyunsaturated fats in small quantities can help to d

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

crease total cholesterol. Examples of polyunsaturated Fats - would be vegetable oil and palm oil.

We also know that eating too much fat leads to health problems and

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

eight-gain, but we do need some healthy fats in our diet. Fats are a source of soluble vitamins A, D and E.

As pointed out before, consuming fats is the major culpri

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

t that leads to fat being on the human body mainly because fats are high in calories. I recommended that people eat less than 20% of total their total calories from f

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

t.

Fats provide hormone production and skin health and protection of vital organs and insulation Too much fat in the diet however, can increase the risk of a number

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

f lifestyle diseases that are common in the western world

So Please remember…

Limit the saturated fats in your diet - which includes butter, cream, full-

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

at dairy products, fatty meats, cakes, pastries and fried foods.

Choose lean meats where possible and trim visible fat and skin before cooking

Select lo

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

w fat dairy products where possible

Be aware of the hidden fats in processed foods and foods high in salt

Choose liquid fats over solid fats e.g. olive and

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

canola oil over butter

Include amounts of unsaturated or ‘good fats’ in your diet. Sources include fish, olive and canola oil, nuts and avocado

Also try

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

o include the good omega-3 fats daily – fatty fish such as salmon, tuna, and sardines are good sources and try to eat three fish meals a week if you can.

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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Advice Pool - Is Your Fat Being Threatened

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