Advice Pool - Health and Fitness

If you're like me, you probably wish that there was a way for you to lose weight without having to put in much effort, right?

Everyone knows the importance of exercise and how it helps us with weight loss, but on some days don't we al

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

l wish we can just sleep in bed and lose weight at the same time?

Well, I've got some great news for you...

Sleep is a critical part of your weight loss program!

This is a little-known fact, but did you know that sleep can affect yo

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

r weight? Rather, it's the lack of sleep that can make you put on unnecessary weight. You may actually lose more weight if only you were to sleep more every day. What an intriguing thought, isn't it?

In a review of several studies

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

examining the impact of sleep on the regulation of metabolism, Dr. Eve Van Cauter, Professor and Research Associate at the University of Chicago, noted that the association between hormones and sleep was identified more than 30 years a

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

o when it was reported that adult men secrete growth hormone during the early phase of sleep. Since then, research has indicated a harmful effect of sleep loss on the endocrine system and glucose modulation.

One study examined the eff

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

ect of sleep debt and sleep recovery on hormone concentrations and glucose tolerance in healthy males ages 18-27. One week of sleep restriction produced dramatic results: a 30 percent slower response to both the glucose tolerance test

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

nd acute insulin response compared with results in rested subjects. Sleep deprivation also raised the 24-hour cortisol profile.

Another study found that sleep deprivation resulted in 30 percent lower levels of leptin. Amazingly, the e

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

ffect is similar to that observed with caloric restriction (3,000 calories over 3 days), signaling a negative energy balance.

A more recent study examined the effect of 10 vs. 4 hours of sleep on appetite. Subjects who slept 4 hours w

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

re always hungry and craved starchy, sweet, and salty foods. These results suggest that sleep deprivation produces a signal mimicking negative energy balance, inducing people to eat and thereby predisposing to obesity.

These results i

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

ndicate an association between sleep debt and obesity. Sleep deprivation would affect glucose tolerance and leptin levels and increase the appetite for unhealthy foods. She noted that sleep restriction would have greater impact on obes

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

individuals, who have higher leptin levels to begin with, and on older adults.

Dr. Van Cauter also noted that the studies were performed in males only. Because females have higher baseline levels of some hormones (e.g. leptin), sleep

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

restriction might have worse effects in women than in men.

Hey, did you notice the groups which were mentioned specifically in the last 2 paragraphs that may be more severely affected by sleep deprivation? I'll recap them here again:

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

(1) obese individuals, (2) older adults, and (3) women.

That's really crucial for us because this means if you're a woman over 40, not getting enough sleep will probably make you feel hungry constantly and crave for all the unhealth

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

foods even more as compared to other people. And the more overweight you are, the more you may be affected by the lack of sleep.

Not surprisingly, another study has indeed found an inverse relationship between increased body mass ind

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

ex (BMI) and sleep duration in women. That is, women who do not sleep enough tend to be more overweight than women who get sufficient sleep.

And just in case you still believe in the myth that "Oh, it's alright because I'll catch up o

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

my sleep on the weekends", you should note that Dr. Van Cauter also made the following observation: Sleep debt is generally not paid back fully by weekend sleep. I suppose this is kind of like the saying "An apple a day, keeps the do

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

ctor away" -- eating 7 apples on Sunday instead of 1 a day just isn't going to give you the same results!

Now, I'm _not_ saying that you don't have to exercise and all you have to do to lose weight is to sleep it off. Exercise, streng

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

h training and physical activities in general are vital components of a permanent weight loss program.

It's simply that if you don't sleep enough, you'll just be making it more difficult for yourself to lose the extra weight. There's

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

no point in sabotaging your chances of weight loss success if it's a simple matter of making sure you get enough sleep every night, right? I mean, how much easier can it get?

According to William Dement, Stanford University sleep re

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

earcher, adults need about 8 hours of sleep a night. Try your best to get this amount every day, and you'll reduce one more obstacle in your path to attaining your desired ideal weight. Simple idea, isn't it?

Copyright 2005 Tracy Le

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

HTTP = HTML link (for blogs, profiles,phorums):
<a href="http://www.advicepool.org.ua/article/276897/advicepool-Are-You-Overweight-Because-Youre-Not-Sleeping-Enough.html">Are You Overweight Because You're Not Sleeping Enough?</a>

BB link (for phorums):
[url=http://www.advicepool.org.ua/article/276897/advicepool-Are-You-Overweight-Because-Youre-Not-Sleeping-Enough.html]Are You Overweight Because You're Not Sleeping Enough?[/url]

A top complaint from audience members is that many presenters put too much emphasis on PowerPoint and technology while neglecting the message and interaction with participants. One way to deliver more effective presentations that improve your connection to your audience is to add a remote control to your presentation tools.

Invented by an innovative dating service entrepreneur, Jewish speed dating has become a phenomenon in the singles world. It takes careful coordination, a large member base in the immediate and surrounding area and a lot of work on the part of the dating service to pull it off and make it successful.

It used to be that anyone prescribed a gluten-free, or a wheat-free, diet had difficulty finding foods which were tasty. Not so anymore! Food product development has advanced to the point where there is a wide variety of high quality gluten-free foods on the market.

Tags

Links

Advice Pool - Are You Overweight Because You're Not Sleeping Enough?

Related Articles: