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    How your memory works

    Short-term memory: focuses on what is happening now; the mind filters out what’s irrelevant.

    Mid-term memory: the mind stores information that’s bizarre, unusual, shocking, important, interesting and that’s relevant to you in some way.

    When doing any routine action, when you’re doing it automatically, like being on a
    According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product
    uto-pilot, let’s say while you are driving, if something unusual happens then you’ll remember it for a while – e.g. a deer running across the road. Other mid-term memory events could be key scenes in a movie, or someone being exceptionally kind or horrible when it’s not expected.

    While reading this article, you may not find all of what your
    ; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

    Examples of combination products may in
    reading interesting but you’ll remember the parts that you find of value to you, or that challenge you, or that you disagree with.

    Long-term memory: applies to actions you repeat on a regular basis, like driving, or riding a bike, how to tell the time, how to tie your shoelaces; you may have noticed how difficult it can be to a child to tie
    lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

    their laces for the first time and how easily and unconsciously you can do it now, without even a conscious thought.

    Memory is created by repetition or if something is important to you.

    I’m going to tell you a story about a lady called Karen, while I’m telling it see if you can work out which parts of the story are related to her short, mi
    here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe
    or long-term memory:

    Karen was on her way to an interview. It’s a route she knows well since she used to work near this place a few years back. On the way she saw a shop window all smashed up, lots of police and the sound of sirens screeching in the background. She started to hurry past the scene, she felt uncomfortable, a bit shaken, she’
    d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

    Combination pro
    never seen anything like that before; looks like there’d been a robbery, maybe someone had got hurt, she shivered inside as she scurried past. When she arrived at the building for the interview, Karen was shown down a flight of stairs, along a very long corridor, filled with some really beautiful and unusual works of art; at the end of the
    ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc
    corridor, in a small office, she was introduced to Miss Loretta Higgins, who took her through to the interview room and the interviewer.

    From Karen’s story, which parts are short-term, mid-term or long-term memory?

    Do you have a good or bad memory?

    We brain-wash ourselves by telling ourselves things like: “I have an awful memory” or “I ha
    easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi
    e a selective memory”. Your brain is like a sponge, it picks up millions of pieces of information all the time all around us. When we believe we can’t remember often we are blocking parts of our memory, either because we’ve brainwashed ourselves into believing we don’t remember or it doesn’t serve us to remember something at that moment in t
    nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically
    me, especially if it’s a painful memory.

    We also say to people: “Don’t forget”, and because the brain doesn’t process negatives we hear the word ‘forget’. What you could say is: “Please remember…”

    Let me ask you a question: when you come home do you always put your keys in a specific place? So you always know exactly where they are, right?
    and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ
    And what happens when you put them in a different place, just that once? Just like your memories, you haven’t actually lost your keys or your memories, you simply can’t find them because they’re not where you expect them to be – so you say to yourself “I’ve lost my keys, I can’t find them.” And we say the same about our memory, we brain wash
    ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi
    ourselves about our memory telling ourselves again and again what we can or can’t remember. Eventually, you do find the keys and often we do recall many memories we think we’ve forgotten, sometimes only moments later.

    How memories are triggered

    Our memory can be triggered in a number of ways using our 5 key senses:
    - Visual associatio
    ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

    Following aspects would a
    n: where a picture reminds you of something; e.g. a photo of the sea and sand may remind you of a holiday.
    - Kinaesthetic association: where a feeling reminds you of something; when someone tells a good joke and you start laughing, it often sparks of other jokes and more laughter.
    - Auditory association: where a sound brings back a
    dd to the challenges in developing combination products:

    Which markets to tap where the combination products can do fairly well?
    Which combination prod
    memory, like a song that’s associated with a particular event or situation.
    - Olfactory association: where a smell brings back a memory, a lady’s perfume
    - Gustatory association: where a taste brings back a memory; your eating a delicious chocolate brownie with hot fudge sauce and it reminds you of your last holiday to the USA!

    Ev
    cts are meaningful and rational?
    Which therapeutic categories to select?
    Which Combinations can address unmet needs of the patients?
    Do combin
    rybody’s memory is absolutely perfect!

    You remember your home phone number because you’ve said it so many times, you may not remember your mobile number because you don’t need to tell it to people, as soon as you ring them on their mobile your number shows up and they save it! Therefore, you don’t need to remember it, so you don’t!

    Why ar
    tions increase the patient compliance?
    What would be the developing cost?
    How to tackle the risks encountered during combination product developmen
    there things we don’t remember? Because we tell ourselves that we don’t remember things. And our minds are like perfect servants, whatever we tell it over and over again, it follows our instructions.

    If I were to ask you for the phone number of the previous home you lived in, what’s the 1st thing you tell yourself? “I can’t remember.” So
    t?

    As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel
    ou won’t remember; we do this repeatedly with many things that we want to remember and then we tell ourselves – I have a really bad memory, so you do! It becomes a self-fulfilling prophecy.

    What could you say differently to yourself so that you give yourself the possibility of recalling that information? “I know I know it because I used t
    ping new procedures for reviewing their safety, efficacy and quality.

    Professional from academic institutions, pharmaceutical industries, health care indust
    o say it so many times, I’m sure it’ll come back to me shortly.” And maybe it will, or maybe it won’t – at least you’re leaving the door to the possibility of remembering it open rather than closing it without a 2nd chance.

    There are four steps to learning and remembering:

    Step 1: unconsciously unskilled
    Step 2: consciously unskilled
    y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products
    br> Step 3: consciously skilled
    Step 4: unconsciously skilled

    If you have ever learnt to drive then this example will demonstrate the above concept: at first we don’t know that we don’t know how to drive; then we realise how much we don’t know; then we know how to drive and need to think through each step consciously and carefully; an
    .

    As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de
    finally, we drive without thinking about it, unconsciously.

    There are things that we do, that we know and that we remember automatically because we’ve repeated them so often, like brushing our teeth, knowing which drawer in which cupboard to find our clothes, routes that we take regularly, etc.

    What knowledge or memories are so ingrained
    elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

    Companies that provide selfless information through particip
    n your mind, that you know and remember them automatically, easily and effortlessly?

    Remember – to help your memory:
    Change your belief and the words you say to yourself. “I know that I know it, I’m sure I’ll remember in a short while.” – keep the possibility open. And you can say “Please remember..” instead of the term ‘Don’t forget…


    tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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