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The easiest kinds of motivation to analyse, at least superficially, are those based upon obvious physiological needs. These include hunger, thirst, a

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

nd escape from pain.

The analysis of the processes underlying such motivations can make use of research on animals, in ethology, comparative psychol

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

ogy, and physiological psychology, and the hormonal and brain processes involved in them seem to have much in common at least across all mammals and

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

probably across all vertebrates.

However, in humans, even these basic fundamental motivations are modified and mediated through social and cultural

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

influences of various kinds: for example no analysis of hunger in humans could ignore the issues of eating disorders such as anorexia nervosa and obe

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

sity, for which the parallels in other animals are unclear.

Even in animals, it is clear that the earlier homeostatic "depletion-repletion" models o

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

f such motivations are no longer adequate, since many animals feed on a precautionary rather than a reactive basis, most obviously when preparing for

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

hibernation.

At the next level are motivations that have an obvious biological basis but are not required for the immediate survival of the organis

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

m. These include the powerful motivations for sex, parenting and aggression: again, the physiological bases of these are similar in humans and other

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

animals, but the social complexities are greater in humans (or perhaps we just understand them better in our own species).

In these areas insights f

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

om behavioral ecology and sociobiology have offered new analyses of both animal and human behaviour in the last decades of the twentieth century, tho

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

ugh the extension of sociobiological analyses to humans remains highly controversial. Perhaps similar, but perhaps at a rather different level, is th

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

e motivation for new stimulation - variously called exploration, curiosity, or arousal-seeking.

A crucial issue in the analysis of such motivations

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

is whether they have a homeostatic component, so that they build up over time if not discharged; this idea was a key component of early twentieth cen

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

tury analyses of sex and aggression by, for example, Freud and Konrad Lorenz, and is a feature of much popular psychology of motivation.

The biologi

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

cal analyses of recent decades, however, imply that such motivations are situational, arising when they are (or seem to be) needed to ensure an anima

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

l's fitness, and subsiding without consequences when the occasion for them pases.

The most obvious form of motivation is coercion, where the avoidan

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

ce of pain or other negative consequences has an immediate effect. When such coercion is permanent, it is considered slavery.

While coercion is cons

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

idered morally reprehensible in many philosophies, it is widely practiced on prisoners or in the form of conscription. Critics of modern capitalism c

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

harge that without social safety networks, wage slavery is inevitable. Successful coercion sometimes can take priority over other types of motivation

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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