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The purpose of asking hypnotic, trance-inducing questions is to put the person in a position of accessing useful and meaningful information. It just so happens that such questions are hypnotic, even though any kind of hypnotic trance is not the intent of asking such provocative questions. Asking a question can put a person into a hypnotic-like trance stat

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

e. You can tell they are in a trance because their eyes will move around as they access the information required to answer the question. As they access that information, they are in a trance state. A trance state is generally highly focused, though relaxed. Even as you read these words, you are in somewhat of a trance as you are probably (and hopefully) u

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

awares of your surroundings. You are focused on the translation and interpretation of these symbols called letters and words into meanings. When a person is accessing internal information they are often not aware of their external surroundings. A good question will require a person to focus their attention on their internal landscape to gather the informa

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

tion. During this time, they will be mildly, or in some cases extremely, unaware of their external environment and very likely in a hypnotic-like trance state.

The purpose of asking hypnotic, trance-inducing questions is to put the person in a position of accessing useful and meaningful information. It just so happens that such questions are hypnotic, ev

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

n though any kind of hypnotic trance is not the intent of asking such provocative questions. For example, the question “where would you like to go to dinner tonight” is really not provocative and does not require any kind of depth to access the information. The question “How would you describe your first dinner date” does require some remembering; while a

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

ctually remembering and gathering that information, a person will be focused in a hypnotic trance-like state.

Asking any question necessarily directs a person’s mind in a particular direction; as such, any question is a suggestion, in the hypnotic use of that term. Hypnotic suggestions are simply words which automatically conjure up images. For example,

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

hen I ask “can you imagine yourself sitting on the back of a white winged horse flying through the sky” you must necessarily entertain that image in your mind to understand it at all. That question directed your mind to a particular image. I can ask the question “do you think it might rain today?” on a perfectly clear day but still the mind of the listene

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

r will be taken to the image of a rainy day. That’s how suggestion works. It takes the mind in a particular direction. In a like fashion, the mind does not imagine negatives so the statement “don’t forget to lock the door only conjures up images of forgetting to lock the door. A much better suggestive statement would be “remember to lock the doors.”

This

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

information can become practical when dealing with others because it is a way of directing their attention to a topic you want. For example, let’s say you are dealing with an employee who has made a mistake in work. Rather than focus on the mistake, you can ask “what would it look like if you did it correctly?” That question requires the person to access

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

a mental image of something which actually did not happen, but could have – and should have. The question leads the mind to a mental image of correct action which is a much better reinforcement that rehashing the mistake. If a teenager is being oppositional, a parent can ask “let me ask you this, what would need to happen for you to be more cooperative?”

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

his question requires the teenager to access images of cooperative behavior to convey to the parent what might be needed for that behavior to occur. This is much better than “stop being oppositional” because, again, the mind does not visualize negatives. The word “stop” cannot be visualized but “being oppositional” certainly can be.

There are two genera

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

formats for asking these kinds of penetrating, trance-inducing questions. Both formats rely heavily on the single, simple word “if.” I like to refer to “if” as “Imagination Fascination” because using “if” requires the mind to imagine something-- and hopefully become quite fascinated in that imagination, whi

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

ch is a trance state. The first question begins with “what would happen if” and the second question begins with “what prevents (behavior or action) from happening. The second question does not use “if” directly, but the need to become fascinated with an imagination is still necessary. If a person says they can’t do something (or won’t do something), a goo

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

question to ask is “what prevents you from doing that?” Or, you could ask “what would happen if you did do it?” Both questions require a high degree of internal focus to answer, which is often why it’s a difficult question to answer. More often that not “I don’t know” is the response. In such cases you can say “take a guess.” Whatever comes up out of tha

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

t guess arises from their internal machinations and is useful information.

These two formats: “what would happen if…….” and “what prevents……” are hypnotic trance inducing questions and it may take a person a several minutes to respond adequately. You can tell if they are processing the information by observing their eyes. Our eyes tend to move up left,

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

own right or across left or right…when we are accessing internal experience. A person’s eyes can actually reveal a whole strategy of thinking simply by responding to one question. For example, when asking a person who wants to stop smoking “what prevents you from quitting” you may be able to observe their eyes move up right then down left, then up left th

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

en up right and then to the right center and then again up right….There can be a lot of movement as the person accesses internal mental states necessary to answer that question.

Eye movements tend to correlate to different sensory channels. Up right tends to be visual constructions, i.e., imaginations. Up left tends to be remembered visual experiences, i

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

e., memories. Down right is generally feelings and down left is generally internal dialogue. Centered and over to the right is generally constructed (imagined) auditory and centered over to the right is generally remembered auditory. Straight on centered is generally visual constructed or remembered. It often takes some calibration to find out what any pa

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

rticular persons eye movements represent. You can ask a simple question like “do you remember what you had for lunch last week” and you’ll find out what eye movements represent remembered. Then you can ask “what will you be doing next Friday night” and you can then observe eye movements for constructed or imagined experience.

When you ask a person these

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

inds of suggestive questions, you are leading them; you are a leader. Take some time to observe people’s eyes as they think about answers to questions; then practice asking these hypnotic trance-inducing questions. You’ll find them effective tools for gathering meaningful information and directing a person’s attention to content rich regions of their mind

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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